3D Medical Animation: Antibody Immune Response
http://www.nucleusinc.com This 3D medical animation shows how antibodies stop harmful pathogens from attaching themselves to healthy cells in the blood stream. The animation begins by showing normal red and white blood cells flowing through the blood stream. Next, a single pathogen appears onscreen slowly moving toward its destination on the surface of a cell. The tubular extensions on the pathogen are surface proteins which attach to
corresponding surface proteins on a white blood cell, or leukocyte. As the animation continues, more pathogens continue to attach to the white blood cell, rendering it ineffective.
During the immune system response, Y-shaped antibodies begin attacking the pathogen, binding to its surface proteins as the pathogen attempts to anchor to the blood cell. The antibodies completely block the pathogen from attaching to the blood cell, “tagging” the pathogen so
that one of the immune system’s leaner cells, a macrophage, appears onscreen to engulf and digest the pathogen.
Nucleus Medical Art is a leading creator and licensor of medical illustrations, 3D medical animations and interactive multimedia for medical devices, pharmaceutical companies, education, biotechnology, advertising agencies, lawyers, and more. Online at http://www.nucleusinc.com/youtube.
Duration : 0:0:52
That’s more looks …
That’s more looks like opsonisation of antigen, that makes it better target to eat.
@elminz hah, funny.
@elminz hah, funny.
YAAAA MACROPHAGE!!!
YAAAA MACROPHAGE!!!
@Mivsher how does …
@Mivsher how does hiv infect the t helper cells? like how does it disable it thus the whole immune system?
those puny little …
those puny little pathogens got epicly pwned by the antibodies and then munchy-crunched by the mighty macrophages!
The white blood …
The white blood cell was all like, OM NOM NOM NOM
Antigens do not …
Antigens do not just float in the blood for fun. Well we could suppose that antigens, that do ‘float’ in the blood freely, are toxins – they are actually released into the blood. And the cells that are responsible for removing this toxins re lymphocytes – white blood cells/phagocytes (eg macrophages) that engulf the toxins, lysosymes (digestive enzymes) are released from lysosome. And this is the end of the toxin.
You mean which …
You mean which parts will be ‘under’ and ‘above’ the plasma membrane? Imagine antibody as a letter Y. The ‘branches’, the top bits are the binding sites, where antibody-antigen complex is being formed. Those ‘branches’ are also called variable regions). So they are the ones which are going to be ‘above’ the plasma membrane. The constant region, the stem, will be ‘under’ the plasma membrane.
Antibodies don’t communicate with macrophages.Macrophags release cytokines,triggering the immune response.
@Mivsher And what …
@Mivsher And what type of cell from the immune system binds to the antigens floating in the blood? That’s a really complex question i know..
@Mivsher But i have …
@Mivsher But i have a question… If the antibody was a transmembrane protein, which parts of the antibody will be able to go through the plasma membrane? And suppose the antibody is a secreted one, which parts of it will associate with macrophages? Will it bind with the macrophage on the antigen-binding site?
Thanks,
David
the giant white …
the giant white thing is the white blood cell
and they are not big they are very small
that wite thing …
that wite thing wasent very nice pshh just minds its own buisness then gets eaten by a giant white thing
koool
koool
I will try to share …
I will try to share my knowledge.
1. Yes, they are antigens. How it actually works: There are B cells, make soluble antibodies. Antibodies bind to the antigens on viruses and bacteria, forming and antibody-antigen complex. This prevents the antigens from attaching to a cell and infecting it.
2. The pathogens (viruses, bacteria, toxins) attack any healthy cell they can. Eg in AIDS case, HIV virus destroys T-helper cells/lymphocytes (the ones that speed up immune response).
‘ The antibodies …
‘ The antibodies completely block the pathogen from attaching to the blood cell, “tagging” the pathogen so that one of the immune system’s leaner cells, a macrophage, appears onscreen to engulf and digest the pathogen. ‘
• So, do the Antibodies just bind to the Antigens in order to ‘tag’ the Pathogen for the Macrophage (Phagocyte) to engulf + digest them?
• When the Antibodies bound to the Antigens of that Pathogen; will new antibodies retract the Pathogens off that White Blood Cell?
I Read all of the …
I Read all of the video’s description – Just have a few questions for anyone willing to answer:
As explained in the description:
‘ The tubular extensions on the pathogen are surface proteins which attach to
corresponding surface proteins on a white blood cell, or leukocyte. ‘
• Are Tubular extensions on the Pathogen ANTIGENS?
• Do Pathogens attack any type of Cell of normally just White Blood Cells?
You were taught …
You were taught that HIV was caused by a bogie eating all the bagpipes at medical school!?
we were taught …
we were taught this at medical school!!
Though using these animations to teach us would have been way cooler!!!!
Wow this is so cool …
Wow this is so cool.
I wish I knew more about this.
I want to go to school so bad!
oh my god, if i get …
oh my god, if i get one of those, i could die or something
All pathogenic …
All pathogenic organisms are propelled throughout the body via the blood stream. Thats how they reach their target tissues. It is while surfing through the various components of the body, do they finally attach themselves to their tissue of choice.
Besides they have various means of avoiding or manipulating the body’s immune system, hence the process of an infection begins.
They have a pre-existing genetic know how of which tissue to target. Like the polio virus targets neural tissue only.
But what propels …
But what propels the viruses? I would think the blood stream, how do they then get to where the chemical signals them?
Viruses and other …
Viruses and other pathological microbes have specific tissue targets, which help the bind to their tissue of choice. Like the Hepatitis virus binds to liver cells. Besides on of the means by which they are guided towards their target tissue, is probably chemotaxis, or chemical signalling.
Antibodies on the other hand have a brief idea of what belongs to the body and what is foreign.
Very cool… what …
Very cool… what is it that guides the viruses and immunoglobulins to the right attachments? Or is it all random bumping around, and this was dramatized for clarity
Thats so awesome!!!
Thats so awesome!!!